F2

Rename selected file

F3

Search remote files

F5

Refreshes local and remote file and folder views

Tab

Switches to the next view

Alt+Arrow Down

Transfers the currently selected item to an item of the same name in the other pane

Alt+Arrow Up

Navigates up one line in a tree view (same as Up Arrow), navigates to parent folder in file view

Ctrl+B

Add Bookmark

Ctrl+Shift+B

Manage Bookmarks

Ctrl+C

Stops the current operation

Ctrl+D

Disconnects from server

Ctrl+E

Show files currently being edited

Ctrl+I

Directory listing filters

Ctrl+M

Manual transfer

Ctrl+Shift+N

Create a New Directory

Ctrl+O

Enable directory comparison

Ctrl+P

Process queue

Ctrl+Q

Exit

Ctrl+R

Reconnects to server

Ctrl+S

Opens the Site Manager

Ctrl+T

Opens a new Tab

Ctrl+U

Preserve timestamps of transferred files

Ctrl+Y

Toggle synchronized browsing

Ctrl+W

Close tab

Enter

Transfers the currently selected item if it is a file or expands it if it is a directory

Ctrl+Page up/Page Down

Switch to next/previous tab

Arrow Up/Arrow Down

Move up one item / down one item in the current view

Arrow Left

Up one level in a tree view

Arrow Right

Down one level in a tree view, if there are subfolders. Pressing once expands a collapsed node. Pressing again steps down into it.